Pre-synaptic dopaminergic compensation after moderate nigrostriatal damage in non-human primates
نویسندگان
چکیده
منابع مشابه
Nigrostriatal dopamine system dysfunction and subtle motor deficits in manganese-exposed non-human primates.
We tested the hypothesis that movement abnormalities induced by chronic manganese (Mn) exposure are mediated by dysfunction of the nigrostriatal dopamine system in the non-human primate striatum. Motor function and general activity of animals was monitored in parallel with chronic exposure to Mn and Positron Emission Tomography (PET) studies of in vivo dopamine release, dopamine transporters an...
متن کاملTetrahydroisoquinoline lacks dopaminergic nigrostriatal neurotoxicity in mice.
1,2,3,4-Tetrahydroisoquinoline (TIQ) has been reported to occur in human brain, with its content being 10-fold higher in the brain of a patient with Parkinson's disease (PD) than in that of a control subject. This congener of the neurotoxin 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP) could be formed in brain by the condensation of phenylethylamine with metabolically formed formaldehyde....
متن کاملDopamine transporter imaging with [123I]-beta-CIT demonstrates presynaptic nigrostriatal dopaminergic damage in Wilson's disease.
OBJECTIVES The most common neurological manifestations in Wilson's disease are parkinsonism and dystonia. These are assumed to be due to striatal injury, which has been repeatedly demonstrated by pathology and CT or MRI. The substantia nigra has not been shown to be damaged in pathological studies. However, there have been clinical and imaging studies suggesting presynaptic nigrostriatal injury...
متن کاملSparganosis in non-human primates.
CHAI , D. FARAH, I. & MUCHEMI , G. 1997. Sparganosis in non-human primates. Onderstepoort Journal of Veterinary Research, 64:243-244 Over a period of 15 years, the larval stages of Diphyllobothri id tapeworms of the genus Spirometra were found during routine necropsy in four of 3 007 non-human primates at the Institute of Primate Research (IPR) .
متن کاملNon-human Primates
Introduction Less than 1⁄4 of one percent of all lab animals needed in the U.S. are non-human primates. Approximately 30 different species are studied by the research community.1 Many historic scientific breakthroughs, such as the discovery of the Rh factor and the development of a live polio virus vaccine were achieved through research with non-human primates. Today they are considered extreme...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: Journal of Neurochemistry
سال: 2008
ISSN: 0022-3042,1471-4159
DOI: 10.1111/j.1471-4159.2008.05268.x